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Scleroderma SlideShare

Scleroderma. 1. SCLERODERMA. 2. Systemic sclerosis is a rare, heterogeneous, slow- motion disease, with (allegedly) a small window of opportunity to fundamentally change the course of the disease. 3. derived from greek and means hard skin Affects about 250/million = 7500 Canadians Affects mainly women in the prime of their life women: men ratio. Scleroderma. 1. Sclerodermasystemic sclerosisDr / Hytham Nafady. 2. DefinitionMultisystem collagen vascular disease ofunknown etiology characterized by• fibrosis of the skin with• involvement of the internal organs. 3 Diffuse scleroderma in association with rapid progression of skin involvement 2. Pathology - intimal hyperplasia of the interlobular artery - fibrinoid necrosis of afferent arterioles - glomerulosclerosis 3. Proteinuria, abnormal sediment, azotemia, 4. Microangiopathic hemolytic anemia (scleroderma renal crisis), renal failure 28 Scleroderma Scleroderma: It is a term which includes a heterogenous group of limited and systemic conditions causing hardening of the skin. Systemic sclerosis: It is an extension of the disease process which implies involvement of both skin and other sites, particularly central internal organs. 9 Upcoming SlideShare. Loading in SCLERODERMA renal CRISIS -dreadful complication of SSc. 117. 20-25% pts 118. < 4 yrs of onset of diseases 119. Survival <10 % until ACEI 120. It is due to OBLITERATIVE VASCULOPATHY of renal cortical arteries. 121. RBF JGA hyperplasia renin secretion RAAS renal vasoconstriction malignant HTN..

  1. Systemic sclerosis 1. SyStemic ScleroSiS 2. Case scenario Manjees,27 yrs D1/1 Duration of illness-5 years c/o raynaud's phenomenon+fingertip ulceration Not a/w pain,h/o digital gangrene a/w skin binding down started from B/L forearms gradually increasing over the course of 4-5 years to involve whole body Restriction of hand and wrist movements Breathlessness Difficulty in swallowing with.
  2. [R.E.A.D] LIBRARY Reversing Scleroderma Kidney Filtration The Raw Vegan PlantBased Detoification Regeneration Workbook for Healing Patients Volume 5 ^^Full_B
  3. Scleroderma is a long-lasting autoimmune disease that affects your skin, connective tissue, and internal organs. Learn more about the types, causes, risk factors, symptoms, diagnosis, treatment.
  4. This video contains a detailed and simplified explanation of systemic sclerosis and scleroderma. We discuss the pathophysiology, presentation, features, inve..

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Systemic sclerosis..scleroderma - SlideShar

Scleroderma Scleroderma is a disease that can cause thickening, hardening, or tightening of the skin, BV's and internal organs. F>M Types Localized: usually only affects the skin on the hands and face. Systemic: more serious and affects connective tissue in many body parts, including internal organs. 19 Diffuse scleroderma affects skin on the face and areas below and above the elbows and knees. The progression of diffuse scleroderma typically involves skin thickening over the first 1-3 years with corresponding development of organ involvement, progression slows and stabilizes after 1-2 years, and skin softens and disease improves after year 5 Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse cutaneous systemic sclerosis with divergent patterns of organ involvement, autoantibody profiles, management, and progn

Kikuchi K, Kadono T, Ihn H, et al. Growth regulation in scleroderma fibroblasts: increased response to transforming growth factor-beta 1. J Invest Dermatol 1995 ;105: 128 - 132 . Crossre scleroderma and recurrent digital ulcers but it does not reduce the severity of the Raynaud events. Other therapies include the use of statins - the drugs used to lower cholesterol. Studies suggest statins can reduce digital ulcers in patients with scleroderma. Use of anti-oxidants and a local injection of Botox i Scleroderma renal crisis is much less common in limited scleroderma although it can occur, often early in the disease. Approximately 80% of all major kidney problems occur within the first 4 to 5 years of the disease. For unknown reasons, serious kidney problems are more common in men and with patients who had an older age of disease onset.. Scleroderma is a chronic disease of skin, most often also affects our digestive system. The prime causative factor of this disease is our unwholesome dietary habits. If you're looking for ways to plan the diet of scleroderma or seeking information on how to detox your gut, or simply want to feel your best, this video has got you covered

Objective: Our purpose was to determine the involvement of the female genital tract and its functional consequences on menstrual and sexual aspects in systemic sclerosis. Study design: Sixty women with systemic sclerosis and 23 age- and disease duration-matched women with either rheumatoid arthritis or systemic lupus erythematosus were surveyed with a comprehensive questionnaire addressing. Scleroderma is a skin disease of the connective tissue featuring thickened skin that can involve scarring, blood vessel problems, varying degrees of inflammation and pain, and is associated with an overactive immune system.; CREST syndrome is a limited form of scleroderma. Patients with scleroderma can have specific antibodies (ANA, anticentromere, or anti-topoisomerase) in their blood that. Akesson A, Wollheim FA. Organ manifestations in 100 patients with progressive systemic sclerosis: a comparison between the CREST syndrome and diffuse scleroderma. Br. J. Rheumatol. 28(4),281-286 (1989). Rose S, Young MA, Reynolds JC. Gastrointestinal manifestations of scleroderma. Gastroenterol. Clin. North Am. 27(3),563-594 (199

Lupus is a chronic, progressive disease, and treatment is directed toward relief of symptoms with control of damage to the major organs. Controlling the inflammatory process is the main goal, with kidney damage and renal failure as a major concern. Figure 4 Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. The word scleroderma comes from two Greek words: sclero meaning hard, and derma meaning skin. Hardening of the skin is one of the most visible manifestations of the disease Autoimmune disease is a condition in which the body mistakenly attacks itself instead of foreign invaders such as viruses, bacteria, and fungi. The causes of most of the more than 100 know autoimmune diseases are unclear, but they may be linked to genetics, infections, chemical exposure, and a poor diet high in processed grain, sugar and fat Penn H, Howie AJ, Kingdon EJ, Bunn CC, Stratton RJ, Black CM. Scleroderma renal crisis: patient characteristics and long-term outcomes. QJM. 2007 Aug. 100(8):485-94. . Steen VD, Syzd A, Johnson JP. Scleroderma renal crisis constitutes one of the medical emergencies in rheumatology. [ 3] Blood pressure control is the mainstay of therapy in scleroderma renal crisis. Aggressive treatment of.

Systemic sclerosis - SlideShar

Parry-Romberg syndrome, which is also called progressive facial hemiatrophy, overlaps with a condition known as linear scleroderma en coup de sabre. It is a rare, acquired, neurocutaneous syndrome of unknown aetiology. The principle features are atrophy of the soft tissues, and sometimes the bone, on one half of the face or forehead without facial weakness METHODS Scleroderma ascertainment. Subjects with scleroderma were identified from the South Australian Scleroderma Registry, which has been described in detail elsewhere. 7 Briefly, the registry was established in 1993 with the aim of identifying all known patients with scleroderma resident in South Australia. Patients were ascertained from the following sources D Khanna. Diagnosis and treatment of systemic and localized scleroderma Expert Rev. Dermatol. 6 (3), 287-302 (2011) C Denton. Advances in pathogenesis and treatment of systemic sclerosis . Clinical Medicine 2015 Vol 15, No 6: s58-s63 Dra. De Lira CRAIC Mty 3

ABSTRACT: Scleroderma is a rare, life-threatening autoimmune disorder that causes fibrotic changes in the skin and vasculature.Scleroderma renal crisis (SRC) is a potentially fatal complication of scleroderma, with a mortality rate near 10%. A majority of patients who develop SRC will have an established diagnosis of diffuse cutaneous systemic sclerosis (dcSSc) before progressing to SRC Scleroderma Foundation Cuando usted se hace miembro de la Scleroderma Foundation, favorece el cumplimiento de nuestra misión de apoyar, educar e investigar. Su donativo ayuda a financiar programas en cada una de estas tres áreas: • Destinamos a investigación un presupuesto anual mínimo de un millón de dólares. • Ayudamos a lo

Update on Pulmonary Arterial Hypertension in Scleroderma

A. Pursed lips and masklike facies of a patient with scleroderma. B. Bone resorption (arrows) related to scleroderma. (Reprinted from Albilia et al with permission from the Canadian Dental. This past October, the Scleroderma Foundation Greater Chicago Chapter was pleased to welcome Dr. Jaehyuk Choi to Northwestern for our Patient Education Conference. Dr. Choi's background includes both medical and post doctoral study at Yale University, and he is now an assistant professor at Northwestern University in dermatology, biochemistry, and molecular genetics Systemic sclerosis is an autoimmune connective tissue disease, which is characterised by immune dysregulation and progressive fibrosis that typically affects the skin, with variable internal organ involvement. It is a rare condition that affects mostly young and middle-aged women, resulting in disproportionate morbidity and mortality. Currently, interstitial lung disease is the most common. My skin tightened (due to systemic diffuse scleroderma and RNA polymerase III antibody) on my arms, hands, legs, feet, chest, face and around my mouth. Yes, it is from the scleroderma. Also, be careful with your kidneys. My mom had this disease as well and went into renal failure and lost the function of her kidneys

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Beth Doerfler is also currently contributing to our blog series dedicated to managing nutrition and wellness with scleroderma. Check out her most recent blog post here ! We encourage you to take advantage of our other educational online resources on both YouTube and SlideShare To learn more about topics presented at the Patient Education Conference, visit our YouTube and SlideShare sites for slideshows and videos about managing scleroderma. cramp cramps diet foot health leg nutrition potassium Scleroderma sleep tips vitamin Scleroderma Scleroderma causes patches of tight, hard skin, but can also harm your blood vessels and organs. Learn the causes and treatments of this skin disease. Vitiligo Vitiligo is a disorder that causes patches of skin to become white. It happens because cells that make color in your skin are destroyed

Pseudogout Symptoms & Signs. Pseudogout is a type of arthritis (joint inflammation). Pseudogout has this name because its cause and symptoms resemble those of true gout, but gout is related to the presence or urate crystals diagnosis of scleroderma. Thus, a series of vis-its over time may be necessary to arrive at a spe-cific diagnosis in many patients with polyartic-ular joint pain. In some patients, it may not b

Scleroderma and systemic sclerosis (ssc) an overview. When scleroderma only affects the skin, it is considered localized. However, if it affects the skin and internal organs, it is viewed as systemic, also called. First signs scleroderma. 6 warning scleroderma symptoms & signs visit us to learn more Rumination disorder is the backward flow of recently eaten food from the stomach to the mouth. The food is then re-chewed and swallowed or spat out. A non-purposeful contraction of stomach muscles is involved in rumination. It may be initially triggered by a viral illness, emotional distress, or physical injury

What is Raynaud&#39;s, what is scleroderma?

Scleroderma: Definition, Types, Symptoms, Causes, and

Panniculitis refers to a group of conditions that involve inflammation of subcutaneous fat. Despite having very diverse causes, most forms of panniculitis have the same clinical appearance. The diagnosis is established by a skin biopsy, as there are characteristic microscopic features depending on the cause The American College of Rheumatology and European League Against Rheumatism classification criteria for systemic sclerosis are a significant advancement in the field. This article describes the innovative, rigorous, criteria development strategy that was used. The new criteria build upon previous cr

Tuberous sclerosis (also called tuberous sclerosis complex, or TSC) is a rare, multi-system genetic disease that causes non-cancerous (benign) tumors to grow in the brain and on other vital organs such as the kidneys, heart, eyes, lungs, and skin. It usually affects the central nervous system and can result in a combination of symptoms. Autoimmune diseases have some symptoms in common, including pain, swelling, fatigue, skin rashes, low-grade fever, and trouble concentrating. They're often subtle and hard to pinpoint, and they can be easily mistaken for viral infections, depression, or stress.Complicating things, an estimated 25% of people with autoimmune disease have more than one type The white part of your eye (called the sclera) is a layer of tissue that protects the rest of your eye.When this area is inflamed and hurts, doctors call that condition scleritis. There isn't. Neuromuscular causes include achalasia, scleroderma, or diffuse esophageal spasm. Finally, inflammatory and infectious causes can lead to esophageal dysphagia (eosinophilic esophagitis, candidiasis). Endoscopy is an essential part of the evaluation and can diagnose the majority of these conditions

Systemic Sclerosis and Scleroderma: Visual Explanation for

An extractable nuclear antigen (ENA) panel detects the presence of autoantibodies in the blood that react with proteins in the cell nucleus.These proteins are known as extractable because they can be removed from cell nuclei using saline and represent six main proteins (Ro, La, Sm, RNP, Scl-70 and Jo1) Definition and history Microstomia is the term used to describe a congenital or acquired reduction in the size of the oral aperture that is severe enough to compromise cosmesis, nutrition, and quality of life. In recent years, the development of improved surgical reconstructive techniques, particularly the transfer of regional flaps and vascu.. 476 Learning objectives: • Use the epidemiology and natural history of systemic lupus erythematosus (SLE) to inform diagnostic and therapeutic decisions • Describe and explain the key events in the pathogenesis of SLE and critically analyse th Certain medical conditions, including Crohn's disease, radiation enteritis, scleroderma, celiac disease, obesity and diabetes, can slow movement (motility) of food and waste products through the small intestine; Gastrointestinal tract. Your digestive tract stretches from your mouth to your anus. It includes the organs necessary to digest food.

Pulmonary hypertension happens when the pressure in the blood vessels leading from the heart to the lungs is too high. With pulmonary hypertension, the blood vessels to the lungs develop an increased amount of muscle in the wall of the blood vessels. The heart pumps blood from the right ventricle to the lungs to get oxygen The first symptom of pulmonary hypertension is usually shortness of breath with everyday activities, such as climbing stairs. Fatigue, dizziness, and fainting spells also can be symptoms. Swelling in the ankles, abdomen or legs, bluish lips and skin, and chest pain may occur as strain on the heart increases MSUS has an extremely useful application in daily rheumatological practice in differentiating fluid from soft tissue. In fact, the first clinical application of MSUS was in differentiating fluid-filled Baker's cysts from the calf swelling associated with deep vein thrombosis [].The detection of a fluid collection in joints, bursae, tendon sheaths and soft tissues is a useful sign of. To learn more about topics presented at the Patient Education Conference, visit our YouTube and SlideShare sites for slideshows and videos about managing scleroderma. cramp cramps diet foot health leg nutrition potassium Scleroderma sleep tips vitamin d. Looking for something? Search for: Video Dr. Martin Hogan will be presenting on the topic of oral health care at the annual Patient Education Conference on Saturday, April 18, 2015 in Naperville, Illinois. For more information visit the Scleroderma Foundation's event page here or email GCchapter@scleroderma.org to register for the event

Scleroderma (Systemic sclerosis) - YouTub

Acute kidney injury (AKI), also known as Acute Renal Failure, is a sudden episode of kidney failure or kidney damage that happens within a few hours or a few days. AKI causes a build-up of waste products in your blood and makes it hard for your kidneys to keep the right balance of fluid in your body. AKI can also affect other organs such as the brain, heart, and lungs Yogurt (1 cup nonfat): 625 mg potassium. Salmon (3 oz) 534 mg potassium. Avocado (1/2 cup mashed): 558 mg potassium. To learn more about topics presented at the Patient Education Conference, visit our YouTube and SlideShare sites for slideshows and videos about managing scleroderma. Inspiration, Personal Stories, Uncategorized

antibodies specify scleroderma with polymyositis and severe calcinosis. The autoantibodies are used in confirming diagnosis, predicting disease subset, and potential organ involvement (Chighizola, Raschi, Cesana, Borghi, & Meroni, 2015). In conclusion, scleroderma is a rare disease but one associated with multiple complications and comorbidities David L. Arbit, MD is a member of Summit Health's Rheumatology team. Dr. Arbit has been practicing Rheumatology and Internal Medicine since 1993, and is former chief of Rheumatology at Valley Hospital in Ridgewood NJ. His special areas of interest include Osteoporosis and Rheumatoid Arthritis. Dr Autoimmune diseases can be classified according to several criteria. One of them is the location of the autoimmune attack. Based on this criterion, autoimmune diseases are distinguished into systemic or organ-specific. Although artificial, this classification scheme is useful for orienting patients and primary care physicians to the appropriate. Localized scleroderma is the most common type affecting children. About 90% of children are diagnosed between the ages of 2 - 14. About the same number of adults also get this type of scleroderma.

Scleroderma: An autoimmune condition that causes scar tissue to form in the skin, internal organs (including the GI tract), and small blood vessels. It affects women three times more often than men throughout life, occurring at a rate of 15 times greater for women during childbearing years Scleroderma, also known as systemic sclerosis, is a chronic systemic autoimmune disease characterised by hardening (sclero) of the skin (derma). Scleroderma symptoms, types, causes and related. May 02, 2016 scleroderma is a disease that involves the buildup of scarlike tissue in the skin. Skin symptoms of scleroderma may include (gi) tract are. Description. Neutropenia is defined as a low white blood cell count. There are many forms of neutropenia connected to autoimmune disease. It is important to understand which form is which. Primary neutropenia is diagnosed when there are no other conditions diagnosed (such as lupus, rheumatoid arthritis, or inflammatory bowel disease. Scleroderma. Scleroderma is a term for a group of disorders that causes thick, tight skin, buildup of scar tissue, and organ damage. These disorders fall into two general categories: localized. Definition of Autoimmunity & Autoimmune Disease. Home > ; Definition Definition of Autoimmunity. Autoimmunity is the presence of antibodies (which are made by B lymphocytes) and T lymphocytes directed against normal components of a person (autoantigens).These components are called autoantigens or self-antigens and typically consist of proteins (or proteins complexed to nucleic acids)

Responses are measured on a scale of 1 to 5, with 5 being the best score. 4.6 out of 5 (675 Ratings) Rheumatology. Clinical Research. Accepting new patients. Appointments: Call 908-277-8640 Book Appointment Online Welcome to ANApatterns.org, the official website for the International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP). ICAP was initiated as a workshop aiming to thoroughly discuss and to promote consensus regarding the richness in nuances of morphological patterns observed in the indirect immunofluorescence assay on HEp-2 cells Polyethylene is a thermoplastic polymer that has a variable crystalline structure. It is one of the most commonly produced plastics worldwide, with tens of millions of tons produced every year. It is produced by linking ethylene molecules to a larger molecule that has a branched chain structure. It is commonly used in cosmetics and personal care products, food packaging materials, and medical.

Responses are measured on a scale of 1 to 5, with 5 being the best score. 4.9 out of 5 (470 Ratings) Rheumatology. Accepting new patients. Appointments: Call 973-777-7911 Book Appointment Online Neuromuscular disorders affect your neuromuscular system. They can cause problems with. The nerves that control your muscles. Your muscles. Communication between your nerves and muscles. These disorders can cause your muscles to become weak and waste away. You may also have symptoms such as spasms, twitching, and pain Mixed connective tissue disease (MCTD) is a rare autoimmune disorder. It's sometimes called an overlap disease because many of its symptoms overlap with those of other connective tissue. The symptoms of osteomyelitis can include: Pain and/or tenderness in the infected area. Swelling, redness and warmth in the infected area. Fever. Nausea, secondarily from being ill with infection. General discomfort, uneasiness, or ill feeling. Drainage of pus (thick yellow fluid) through the skin Connective tissue disorders including systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis or scleroderma (and more) are important causes of pericardial diseases. Acute pericarditis following an ST-elevation myocardial infarction, which is also called Dressler's syndrome, should be anticipated and managed accordingly

Trismus, or lockjaw, is a painful condition in which the jaws do not open fully. As well as causing pain, trismus can lead to problems with eating, speaking, and oral hygiene. . It can occur as a. Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affect the development of the bones. People with this condition have bones that break easily, often from little or no trauma. However, the severity is different from person to person. Multiple fractures are common, and in severe cases, can even occur before birth Dr. Linda Lee is a rheumatologist in Berkeley Heights, New Jersey. She treats conditions like rheumatoid arthritis, autoimmune disorders, and Raynaud's phenomenon. See how she can help you today

Scleroderma NEET MDS Entranc

Responses are measured on a scale of 1 to 5, with 5 being the best score. 4.6 out of 5 (409 Ratings) Rheumatology. Accepting new patients. Appointments: Call 973-261-1470 Book Appointment Online Polymyositis is a type of inflammatory myopathy, which refers to a group of muscle diseases characterized by chronic muscle inflammation and weakness. The muscles affected by polymyositis are the skeletal muscles (those involved with making movements) on both sides of the body. Although the disease can affect people of all ages, most cases are seen in adults between the ages of 31 and 60 years

Mri case study- scleroderma - pt

Ainhum is an acquired and progressive condition, and thus differs from congenital annular constrictions. Ainhum has been much confused with similar constrictions caused by other diseases such as leprosy, diabetic gangrene, syringomyelia, scleroderma or Vohwinkel syndrome Management of severe scleroderma with long-term extracorporeal photopheresis. Dermatology. 1998. 196(3):309-15. . Seyger MM, van den Hoogen FH, van Vlijmen-Willems IM, van de Kerkhof PC, de Jong EM. Localized and systemic scleroderma show different histological responses to methotrexate therapy. J Pathol. 2001 Apr. 193(4):511-6. Anthony Surace, MD is a member of Summit Health's Anesthesiology team. Dr. Surace was trained at Mount Sinai Medical Center in New York City in general anesthesiology with a fellowship in pain management. He has always been fascinated with medicine, science, and technology. As an anesthesiologist, it's a privilege for me to be able to stay.

Scleroderma by aseem

Progression and Potential Complications of Scleroderma

Scleroderma/Systemic Sclerosis. Juvenile scleroderma is a connective tissue disorder characterized by an inflammatory phase and endothelial activation secondary to circulating autoantibodies followed by a fibrotic phase of excessive collagen deposition in tissue in a variety of organ systems Leprosy (or Hansen's disease) is a chronic, progressive bacterial infection that can cause disfigurement and disability if left untreated. Discover the symptoms and see pictures. Get the facts. Microangiopathic hemolytic anemia (MAHA) is a microangiopathic subgroup of hemolytic anemia (loss of red blood cells through destruction) caused by factors in the small blood vessels. It is identified by the finding of anemia and schistocytes on microscopy of the blood fil Loss of heterozygosity (LOH) is a cross chromosomal event that results in loss of the entire gene and the surrounding chromosomal region.. All diploid cells, for example most human somatic cells, contain two copies of the genome, one from each parent (chromosome pair); each human copy contains approximately 3 billion bases (adenine (A), guanine (G), cytosine (C) or thymine (T)) Skin disease, any of the diseases or disorders that affect the human skin. Like other tissues, skin is afflicted by all types of pathological changes, and thus skin diseases have a wide range of causes. Learn about the features, types, and treatment of skin diseases in this article

Systemic sclerosisFaces in medicineFecal Incontinence in the Scleroderma PatientScleroderma: State of the Art Management

The antinuclear antibody (ANA) test is widely used as a serological marker of autoimmune disease. Antinuclear antibodies are immunoglobulins or antibodies that bind to one or more antigens expressed within the nucleus of human cells. Used selectively, the ANA test can be a useful laboratory tool to help confirm or exclude the diagnosis of. Buerger's disease, also known as thromboangiitis obliterans, is a rare disorder that, in most cases, affects young or middle-aged male cigarette smokers. It is characterized by narrowing or blockage (occlusion) of the veins and arteries of the extremities, resulting in reduced blood flow to these areas (peripheral vascular disease) Veletri is a new formulation of Epoprostenol approved by the FDA in 2010 for the treatment of PAH, as well as pulmonary hypertension related to scleroderma, lupus, congenital heart disease, diet-pill associated and stimulat associate PH. It is for patient with severe disease that have not responded to conventional therapy Medial epicondylitis is also known as golfer's elbow, baseball elbow, suitcase elbow, or forehand tennis elbow. It's characterized by pain from the elbow to the wrist on the inside (medial side) of the elbow. The pain is caused by damage to the tendons that bend the wrist toward the palm Collagen vascular disease is an autoimmune disease. Lupus, rheumatoid arthritis, and scleroderma are all types of collagen vascular disease

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